Myofibroma as a rapidly growing gingival mass in a 4-year-old boy: a case report

Solitary myofibroma is an uncommon benign soft tissue neoplasm of myofibroblastic origin exhibiting head and neck region predilection but its presence in the jaws is rare. Myofibroma presents as painless mass and may demonstrate rapid enlargement and growth that clinically mimic malignancies. This report presents a 4-year-old male patient with a rapidly growing mandibular gingival mass with some evidence of underlying alveolar bone destruction. Incisional biopsy was performed and the specimen was stained with hematoxylin and eosin and immunohistochemical antibodies for alpha SMA, CD34, S100 and desmin. The diagnosis of myofibroma was made and the lesion was completely excised. The knowledge about microscopic features of this rare neoplasm helps to have a proper diagnosis and avoid unnecessary treatment

Solitary fibrous tumor of retromolar pad; a rare challenging case

Solitary fibrous tumor has a wide spectrum of histopathologic features and many tumors show similar microscopic features. This similarity poses diagnostic challenges to the pathologists and immunohistochemical analysis is required in many cases. Moreover, it is a rare entity in orofacial region which consequently would make its diagnosis more challenging in oral cavity. The knowledge of various microscopic patterns of this tumor contributes to a proper diagnosis and prevents unnecessary treatment. This study reports a case of solitary fibrous tumor in the retromolar pad area and discusses its various histological features and differential diagnoses

Palisaded encapsulated [solitary circumscribed] neuroma of the buccal mucosa: a rare case

The rarity of oral soft tissue spindle cell tumors combined with overlapping microscopic patterns can make challenges in their diagnosis and treatment. Oral cavity palisaded encapsulated neuroma is an uncommon lesion which occurs often on the hard palate. It is essential for oral pathologists to be familiar with its histopathology of this lesion is essential since many lesions are probably diagnosed microscopically as neurofibroma or schwannoma. Here, we report a case of oral palisaded encapsu-lated [solitary circumscribed] neuroma in an unusual site

effect of an angiogenic cytokine on orthodontically induced inflammatory root resorption

Objective: Orthodontically induced inflammatory root resorption [OIIRR] is an undesirable sequel of tooth movement after sterile necrosis that takes place in periodontal ligament due to blockage of blood vessels following exertion of orthodontic force. This study sought to assess the effect of an angiogenic cytokine on OIIRR in rat model

Materials and Methods: In this experimental animal study, 50 rats were randomly divided into 5 groups of 10 each: E10, E100 and E1000 receiving an injection of 10, 100 and 1000 ng of basic fibroblast growth factor [bFGF], respectively, positive control group [CP] receiving an orthodontic appliance and injection of phosphate buffered saline [PBS] and the negative control group [CN] receiving only the anesthetic agent. A nickel titanium coil spring was placed between the first molar and the incisor on the right side of maxilla. Twenty-one days later, the rats were sacrificed. Histopathological sections were made to assess the number and area of resorption lacunae, number of blood vessels, osteoclasts and Howship's lacunae. Data were statistically analyzed using ANOVA and Tukey's honest significant difference [HSD] test

Results: Number of resorption lacunae and area of resorption lacunae in E1000 [0.97 +/- 0.80 and 1. 27 +/- 0.01×10-3, respectively] were significantly lower than in CP [4.17 +/- 0.90 and 2.77 +/- 0.01×10-3, respectively, P=0.000]. Number of blood vessels, osteoclasts and Howship's lacunae were significantly higher in E1000 compared to CP [P<0.05]

Conclusion: Tooth movement as the outcome of bone remodeling is concomitant with the formation of sterile necrosis in the periodontal ligament following blocked blood supply. Thus, bFGF can significantly decrease the risk of root resorption by providing more oxygen and angiogenesis

retrospective analysis of oral langerhans cell histiocytosis in an Iranian population: a 20-year evaluation

Statement of the Problem: Langerhans cell histiocytosis is a rare disease with unknown pathogenesis and is characterized by local or disseminated proliferation of Langerhans cells. There is no previous investigation on prevalence of oral Langerhans cell histiocytosis in Iranian population

Purpose: The purpose of this study was to assess the relative frequency of oral Langerhans cell histiocytosis in an Iranian population and to compare the data with previous reports

Materials and Method: Pathology files of Oral and Maxillofacial Pathology Department of Dental School of Shahid Beheshti University of Medical Sciences from 1992 to 2012 were searched for cases recorded as oral Langerhans cell histiocytosis. A total number of 20 cases were found and the clinical information of patients was recorded

Results: The relative frequency of oral Langerhans cell histiocytosis was 0.34% and the most common location was the posterior mandible. In addition, the mean age of patients was 27 years and there was a definite male predominance. Most lesions were localized and tooth mobility was the most common oral presentation

Conclusion: In Iranian population as in many other countries, the relative frequency of oral Langerhans cell histiocytosis is low. Moreover, tooth mobility and periodontal lesions are the frequent early signs of disease. Therefore, in patients with periodontal problems, good oral health, and no response to the treatment; Langerhans cell histiocytosis must be considered. Additionally, although most cases of oral Langerhans cell histiocytosis are localized, systemic involvement must also be considered and dental professionals have an important role in early detection of the disease

Granulocytic sarcoma [chloroma] presenting as multiple sites in oral cavity: report of a case

Granulocytic sarcoma [GS] is an unusual extramedullary tumor, is composed of immature granulocytic precursor cells. The intraoral occurrence of this tumor is extremely rare. Here we report a case of GS with palatal swelling, gingival lesions in maxilla and mandible and aleukemic presentation in a 45 years old male

Multifocal primary non- Hodgkin's lymphoma of the oral cavity: report of three cases and review of the literature

Objective: Oral non- Hodgkin's lymphoma [NHL] is a relatively rare neoplasm that may develop in the soft tissues or jaw bones, with or without node or marrow involvement. Oral lymphomas are often difficult to diagnose as there are no characteristic clinical features and usually appear as nontender swellings

Case: We describe clinical, radiographic, histopathological and immunohistochemical findings of three cases of multifocal NHLs presenting in the oral cavity

Conclusion: If the oral lesion is multifocal, extra nodal lymphoma must be considered in the differential diagnosis

[Myoepithelioma of a minor salivary gland of the palate: case report]

Myoepithelioma is a rare neoplasm of salivary glands, generally occurring in the parotid and less often in the minor salivary gland of the oral cavity. Vimentin and S100 protein are very sensitive but nonspecific immunohistochemical markers of neoplastic myoepithelium. This report is a rare case of myoepithelioma of the palate of a 25-year-old woman who suffered the disease for two years. The numerous phenotypic expressions of the myoepithelial cell, associated with the rarity of this tumor, may challenge the pathologist